Reverse of Mixing Process with a Two-Dimensional Electro-Fluid-Dynamic Device

TitleReverse of Mixing Process with a Two-Dimensional Electro-Fluid-Dynamic Device
Publication TypeJournal Article
Year of Publication2010
AuthorsLiu C, Luo Y, Maxwell EJ, Fang N, Chen DDY
Journal TitleAnalytical Chemistry
Volume82
Pages2182-2185
Date Published03/15
ISBN Number0003-2700
Accession NumberISI:000275379300005
Keywordscapillaries, CHIP, free-flow electrophoresis, particle separation, proteins
Abstract

Mixing of two solutions into one is a spontaneous process with a net increase in entropy. However, the reverse of the mixing process is usually not possible unless certain conditions are met. A continuous solution stream containing a mixture of two compounds can be separated into two channels, each containing a pure compound, thus reversing the mixing process using a two-dimensional microfluidic electro-fluid-dynamic (EFD) device. When the electric field is strategically applied in the interconnecting channels of an EFD device, the pressure required to direct an analyte into a certain channel can be calculated by using the solutions of electric field and fluid dynamics in the mass balance equation. If the pressure and electric potential at various inlets and outlets satisfy these predetermined conditions, the reverse of a mixing process is observed. Conventional microfluidic devices have been used to introduce samples from interconnecting channels or efficiently mix different solutions into a single channel. The EFD devices expand the spatial separation of analytes from one dimension to two using both the differential migration behavior of analytes and the velocity field distribution in different channel geometries. The devices designed according to these basic physicochemical principles can be used for complete processing of minute samples and to obtain pure chemical species from complex mixtures.

URL<Go to ISI>://000275379300005
DOIDoi 10.1021/Ac902938g