Conjugation of quantum dots and Fe3O4 on carbon nanotubes for medical diagnosis and treatment

TitleConjugation of quantum dots and Fe3O4 on carbon nanotubes for medical diagnosis and treatment
Publication TypeJournal Article
Year of Publication2009
AuthorsShi DL, Cho HS, Huth C, Wang F, Dong ZY, Pauletti GM, Lian J, Wang W, Liu GK, Bud'ko SL, Wang LM, Ewing RC
Journal TitleApplied Physics Letters
Volume95
Pages223702
Date Published11/30
ISBN Number0003-6951
Accession NumberISI:000272627600083
Keywordsal2o3 nanoparticles, biomagnetism, biomedical optical imaging, cancer, carbon nanotubes, cel, fluorescence, hyperthermia, HYSTERESIS, IN-VIVO, nanoparticles, nanotechnology, quantum dots, surface functionalization, tumours, ultrathin polymer-films
Abstract

Quantum dots (QDs) and Fe3O4 nanoparticles were conjugated onto the surfaces of carbon nanotubes (CNTs) for medical diagnosis and treatment. The nanoassembly was designed to meet the specific needs in cancer in vivo imaging and simultaneous treatment. The key functionalities needed for clinical applications were integrated, including CNT surface functionalization for attachment of biological molecules in targeting, drug storage capabilities, fluorescent emissions near the infrared range, and magnetic hyperthermia. CNT-QD-Fe3O4 developed exhibited a strong fluorescence near the infrared region for noninvasive optical in vivo imaging. Magnetization measurements showed nearly reversible hysteresis curves from CNT-QD-Fe3O4 nanoassembly. Fe3O4 conjugated CNT was found to experience hyperthermia heating under alternating electromagnetic field.

URL<Go to ISI>://000272627600083
DOI10.1063/1.3268469