Drug release from pH-responsive thermogelling pentablock copolymers

TitleDrug release from pH-responsive thermogelling pentablock copolymers
Publication TypeJournal Article
Year of Publication2007
AuthorsDeterman MD, Cox JP, Mallapragada SK
Journal TitleJournal of Biomedical Materials Research Part A
Volume81A
Pages326-333
Date PublishedMay
Type of ArticleArticle
ISBN Number1549-3296
Accession NumberISI:000245688500008
Keywordsaqueous-solutions, COPOLYMER, DELIVERY-SYSTEMS, FORMULATION, gel, gelation, GLUCOSE-OXIDASE, in situ, INTERLEUKIN-2, MICELLE, nanoparticles, pH-dependent, POLOXAMER-407, protein release, temperature, thermoresponsive
Abstract

A novel pH-dependent injectable sustained delivery system was developed by utilizing a cationic pentablock copolymer that exhibits a thermoreversible sol-gel transition. Aqueous solutions of the pentablock copolymer, consisting of poly(2-diethylaminoethyl-methyl methacrylate)poly(ethylene oxide) -poly(propylene oxide)-poly (ethylene oxide)-poly(2-diethylaminoethyl-methyl methacrylate) (PDEAEM(25)-PEO100-PPO65-PEO100-PDEAEM(25)) exhibit temperature and pH dependent micellization due to the lower critical solution temperature of the PPO blocks and the polyelectrolyte character of the PDEAEM blocks, respectively. Aqueous solutions of the copolymers above 12 wt % are free flowing liquids at room temperature and form elastic physical hydrogels reversibly above 37 degrees C. Hydrophobic probe absorbance studies indicate that pentablock copolymer micelles increase the solubility of sparingly soluble drugs. Solutions of the pentablock copolymer that form gels at body temperature exhibit sustained zero-order release in in vitro experiments. The release rates of model drugs and proteins were significantly influenced by the pH of the release media, thereby making these polymers ideal candidates for modulated drug delivery. (c) 2006 Wiley Periodicals, Inc.

DOI10.1002/jbm.a.30991
Alternate JournalJ. Biomed. Mater. Res. Part A