First demonstration of adjacent lanthanide separation by lanmodulin

CMI researchers at Lawrence Livermore National Laboratory conducted the research for this highlight

Innovation 
Identified solution conditions that maximize intra-REE selectivity of lanmodulin.

Achievement
Developed a desorption scheme that enables adjacent HREE separation. Achieved 95% purity at yields above 56% for TbIII and DyIII in a single column cycle. The prior HCl elution achieved only 77% purity at similar yields.

Significance and Impact

  • LanM can facilitate adjacent HREE separations that are difficult to achieve using conventional SX ligands
  • Next Steps: Extend new separation methodology to more selective protein variants.

Hub Target Addressed 
Developing highly selective separation from complex sources.
 

Separation of equimolar Tb-Dy feed loaded to 3 mM tREE with (top) isocratic 10 mM HCl (pH 2.0) and (bottom) proprietary effluent. (right) Yield-purity curve showing the enhanced performance of the new separation scheme relative to HCl. The 95% purity Dy fraction can be upgraded to 99.5% purity in a second cycle.
Separation of equimolar Tb-Dy feed loaded to 3 mM tREE with (top) isocratic 10 mM HCl (pH 2.0) and (bottom) proprietary effluent. (right) Yield-purity curve showing the enhanced performance of the new separation scheme relative to HCl. The 95% purity Dy fraction can be upgraded to 99.5% purity in a second cycle.