CMI researchers at Lawrence Livermore National Laboratory, University of Arizona, Ames National Laboratory and Oak Ridge National Laboratory conducted the activity for this highlight
Innovation
We developed an autonomous titration system to rapidly assess ion-extractant interactions in water-organic biphasic systems.
Achievement
The system is a first-of-its-kind, open-source, and modular, allowing it to autonomously determine pKa values for organic extractants in nearly any biphasic solvent system without requiring human intervention. It accelerates throughput by 10+ times compared to manual titration and reduces cost by ~10 times compared to commercial auto titrator.
Significance and Impact
- Novel data analysis embedded in self-developed Rxn Rover software that automatically determines pKa.
- Next step is the continuous operation of the system to analyze the impact of ligand-solvent combinations on biphasic separation.
Hub Target Addressed
Increasing the speed of discovery and integration, developing and applying scientific tools to accelerate technology maturation.
