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WHO grade related expression of TRAIL-receptors and apoptosis regulators in meningioma

TitleWHO grade related expression of TRAIL-receptors and apoptosis regulators in meningioma
Publication TypeJournal Article
Year of Publication2015
AuthorsKoschny, R, Krupp, W, Xu, LX, Mueller, WC, Bauer, M, Sinn, P, Keller, M, Koschny, T, Walczak, H, Bruckner, T, Ganten, TM, Holland, H
JournalPathology Research and Practice
Date Published02
Type of ArticleArticle
ISBN Number0344-0338
Accession NumberWOS:000351116800002
Keywordsanticancer therapy, Apoptosis regulators, bcl-2, cancer-cells, caspase-8, cflip, death receptors, hepatocellular-carcinoma, Immunohistochemistry, ligand, Meningioma, resistance, survival, TRAIL, TRAIL-receptor

xpression was significantly higher in WHO grade II compared to grade I. Bcl-XL and TRAIL-R4 expression correlated with the mitotic activity (Ki67) of the tumor. Furthermore, TRAIL-R2 expression correlated with TRAIL-R4. Bak expression correlated with both, Bcl-XL and Mc1-1 expression. The expression patterns did neither correlate with the progression-free nor with the overall survival of the meningioma patients. Conclusions: Apoptosis-inducing TRAIL-R2 and all key executioners of the extrinsic apoptosis pathway are abundantly expressed in meningioma. For some regulators of apoptosis with opposite functions, the expression of the pro-apoptotic protein significantly correlated with the expression level of the respective anti-apoptotic binding partner, possibly resulting in a steady-state of apoptosis. TRAIL-R2 might serve as a novel therapeutic target in meningioma. (C) 2014 Elsevier GmbH. All rights reserved.

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