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The effect of chemically modified alginates on macrophage phenotype and biomolecule transport

TitleThe effect of chemically modified alginates on macrophage phenotype and biomolecule transport
Publication TypeJournal Article
Year of Publication2016
AuthorsBygd, HC, Bratlie, KM
JournalJournal of Biomedical Materials Research Part A
Volume104
Pagination1707-1719
Date Published07
Type of ArticleArticle
ISBN Number1549-3296
Accession NumberWOS:000377524900015
Keywordsalginate modification, biomolecule transport, cell encapsulation, Engineering, follow-up, gel beads, hydrogels, in-vitro, islet encapsulation, macrophage reprogramming, Materials Science, mechanical-properties, microcapsules, microencapsulated islets, release, surface-chemistry, tissue engineering
Abstract

dies done to examine the permselectivity of the materials. Diffusion of TNF- was completely prevented through some of these materials, while up to 84% was found to diffuse through others. The diffusion of insulin through the materials was statistically consistent. These results suggest that the modification of these materials might alter mass transport in beneficial ways. The ability to control polarization of M phi phenotypes with immunoprotective materials has the potential to augment the success of tissue engineering scaffolds. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1707-1719, 2016.

DOI10.1002/jbm.a.35700
Custom 1

Not AL

Short TitleJ. Biomed. Mater. Res. Part A
Alternate JournalJ. Biomed. Mater. Res. Part A