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Protein patterns template arrays of magnetic nanoparticles

TitleProtein patterns template arrays of magnetic nanoparticles
Publication TypeJournal Article
Year of Publication2016
AuthorsNayak, S, Zhang, HH, Liu, XP, Feng, SR, Palo, P, Nilsen-Hamilton, M, Akinc, M, Mallapragada, S
JournalRCS Advances
Date Published08
Type of ArticleArticle
ISBN Number2046-2069
Accession NumberWOS:000378755200042
Keywordschemistry, deposition, growth, magnetotactic bacteria, mms6, nanocrystals, nanowires, principles, shape, soft lithography

ls in magnetotactic bacteria, provide an alternative method, which can allow synthesis and spatial arrangement under ambient conditions. Mms6, an amphiphilic protein found in magnetosome membranes in Magnetospirillum magneticum strain AMB-1, can control the morphology of magnetite nanoparticles, both in vivo and in vitro. In this work, we have demonstrated the patterning of Mms6 and the formation of patterns of magnetic nanoparticles on selective regions of surfaces by directed self-assembly and control over surface chemistry, enabling facile spatial control in applications such as high density data storage and biosensors. Using microcontact printing we have obtained various patterns of 1-octadecane thiol (ODT) and protein resistant poly(ethylene glycol) methyl ether thiol (PEG) layers on gold surfaces. Atomic force microscopy (AFM) and fluorescence microscopy studies show the patterning of Mms6 on the ODT patterns and not on the PEG regions. Magnetic nanoparticles were grown on these surfaces by a co-precipitation method over immobilized protein. AFM and scanning electron microscopy (SEM) results show the localized growth of magnetic nanocrystals selectively on the Mms6 template, which in turn was determined by the ODT regions. Magnetic force measurements were conducted to assess the localization of magnetic nanoparticles on the pattern.

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Bioinspired Materials

Short TitleRSC Adv.
Alternate JournalRSC Adv.