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Nanoscale patterning of poly (L-lactic acid) films with nanoimprinting methods

TitleNanoscale patterning of poly (L-lactic acid) films with nanoimprinting methods
Publication TypeBook Chapter
Year of Publication2015
AuthorsPeer, A, Dhakal, R, Biswas, R, Kim, J
EditorCampo, EM, Dobisz, EA, Eldada, LA
Book TitleNanoengineering: Fabrication, Properties, Optics, and Devices Xii
Series TitleProceedings of SPIE
PublisherSpie-Int Soc Optical Engineering
ISBN Number978-1-62841-722-7
Accession NumberWOS:000365508500022
Keywordsacid), Adhesion, biodegradable polymer, deformation, fabrication, Nanofabrication, poly (L-lactic, proliferation, scaffolds, schwann-cell growth, soft lithography, surfaces

Biological applications can benefit from nanoscale texturing of materials for biomedical functions. Texturing of biomaterials can increase the available surface area so that they can be coated with larger doses of therapeutic agents. We demonstrate nano-texturing of poly (L-lactic acid) (PLLA) - a prototypical material commonly used for drug-eluting coronary stents and as a template for cell growth. A master pattern consisting of a periodic array was transferred to a PDMS mold. Drop-casting PLLA achieves the best transfer of patterns, with nanoarrays of holes with pitch similar to 700 nm. Nanoimprinting the PLLA films results in shallower and less resolved features.

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