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Nanoscale patterning of biopolymers for functional biosurfaces and controlled drug release

TitleNanoscale patterning of biopolymers for functional biosurfaces and controlled drug release
Publication TypeJournal Article
Year of Publication2016
AuthorsPeer, A, Dhakal, R, Biswas, R, Kim, J
JournalNanoscale
Volume8
Pagination18654-18664
Date Published11
Type of ArticleArticle
ISBN Number2040-3364
Accession NumberWOS:000387858700011
Keywordsacid) film, chemistry, delivery, fabrication, in-vitro, Materials Science, organic-solvents, physics, proliferation, schwann-cell growth, soft lithography, superhydrophobicity, surfaces, Technology - Other Topics
Abstract

s impact on the release of sirolimus, an immunosuppressant agent, coated on the PLLA surface using high performance liquid chromatography/mass spectrometry. We find that PLLA surfaces nanopatterned with 750 nm-pitch nanocup or nanocone arrays exhibit drug release rates significantly lower (25-30%) than that of the flat surface, which is counter-intuitive given the nanopattern-induced increase in their surface areas. Based on diffusion and meniscus curvature minimization analyses, we attribute the decreased drug release rate to the incomplete wetting of the nanopatterned surface. These results provide new insights on how the surface nanopatterning of biomaterials can functionalize the surface and tailor the release kinetics of therapeutic agents coated on it for controlled drug elution.

DOI10.1039/c6nr05197a
Custom 1

Not AL

Alternate JournalNanoscale