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N Methods for Implant Acceptance and Wound Healing: Material Selection and Implant Location Modulate Macrophage and Fibroblast Phenotypes

TitleN Methods for Implant Acceptance and Wound Healing: Material Selection and Implant Location Modulate Macrophage and Fibroblast Phenotypes
Publication TypeJournal Article
Year of Publication2016
AuthorsBoddupalli, A, Zhu, LD, Bratlie, KM
JournalAdvanced Healthcare Materials
Volume5
Pagination2575-2594
Date Published10
Type of ArticleArticle
ISBN Number2192-2640
Accession NumberWOS:000387158900001
Keywordsalginate hydrogels, biologic scaffolds, chondroitin sulfate, Engineering, extracellular-matrix, fibroblasts, foreign-body response, host, host response, hyaluronic-acid, implant location, in-vivo response, inflammatory responses, macrophages, materials, Materials Science, properties, response, skeletal-muscle, Technology - Other Topics
Abstract

d how certain properties such as rigidity, surface shape, and porosity play key roles in the progression of the host response. Several fabrication strategies are discussed to control the phenotype of infiltrating macrophages and fibroblasts: decellularization of scaffolds, surface coatings, implant shape, and pore size apart from biochemical signaling pathways that can inhibit or accelerate unfavorable host responses. It is essential to factor all the different design principles and material fabrication criteria for evaluating the choice of implant materials or regenerative therapeutic strategies.

DOI10.1002/adhm.201600532
Custom 1

Not AL

Short TitleAdv. Healthc. Mater.
Alternate JournalAdv. Healthc. Mater.