| Title | N Methods for Implant Acceptance and Wound Healing: Material Selection and Implant Location Modulate Macrophage and Fibroblast Phenotypes |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Boddupalli, A, Zhu, LD, Bratlie, KM |
| Journal | Advanced Healthcare Materials |
| Volume | 5 |
| Pagination | 2575-2594 |
| Date Published | 10 |
| Type of Article | Article |
| ISBN Number | 2192-2640 |
| Accession Number | WOS:000387158900001 |
| Keywords | alginate hydrogels, biologic scaffolds, chondroitin sulfate, Engineering, extracellular-matrix, fibroblasts, foreign-body response, host, host response, hyaluronic-acid, implant location, in-vivo response, inflammatory responses, macrophages, materials, Materials Science, properties, response, skeletal-muscle, Technology - Other Topics |
| Abstract | d how certain properties such as rigidity, surface shape, and porosity play key roles in the progression of the host response. Several fabrication strategies are discussed to control the phenotype of infiltrating macrophages and fibroblasts: decellularization of scaffolds, surface coatings, implant shape, and pore size apart from biochemical signaling pathways that can inhibit or accelerate unfavorable host responses. It is essential to factor all the different design principles and material fabrication criteria for evaluating the choice of implant materials or regenerative therapeutic strategies. |
| DOI | 10.1002/adhm.201600532 |
| Custom 1 | Not AL |
| Short Title | Adv. Healthc. Mater. |
| Alternate Journal | Adv. Healthc. Mater. |
