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Large Scale Nanoparticle Screening for Small Molecule Analysis in Laser Desorption Ionization Mass Spectrometry

TitleLarge Scale Nanoparticle Screening for Small Molecule Analysis in Laser Desorption Ionization Mass Spectrometry
Publication TypeJournal Article
Year of Publication2016
AuthorsYagnik, GB, Hansen, RL, Korte, AR, Reichert, MD, Vela, J, Lee, YJ
JournalAnalytical Chemistry
Volume88
Pagination8926-8930
Date Published09
Type of ArticleArticle
ISBN Number0003-2700
Accession NumberWOS:000384038400002
Keywordsbiomolecules, chemistry, desorption/ionization, gold nanoparticles, maldi-tof ms, matrix, nanostructures, peptides, proteins, resolution, silver nanoparticles
Abstract

13 NPs for the analysis of twin dozen small metabolite molecules. Many NPs showed Much higher LDI efficiency than organic matrixes in positive mode and some NPs showed comparable efficiencies for selected analytes in negative mode. Our results suggest that a thermally driven desorption process is a key factor for metal oxide NPs, but chemical interactions are also very important, especially for other NPs. The screening results provide a useful guideline for the selection of NPs in the LDI-MS analysis of small molecules.

DOI10.1021/acs.analchem.6b02732
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Nanodomains

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Plant Metabolites

Alternate JournalAnal. Chem.