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Inhibition of MMP-13 with modified polymer particles

TitleInhibition of MMP-13 with modified polymer particles
Publication TypeJournal Article
Year of Publication2016
AuthorsTran, H, Bratlie, KM
JournalSurface Science
Date Published06
Type of ArticleArticle
ISBN Number0039-6028
Accession NumberWOS:000374198600053
Keywordsarginine, carnitine, chemistry, contraction, cytokine, Enzymatic, foreign-body reaction, healing, in-vitro, inhibition, macrophages, Matrix metalloproteinase, matrix-metalloproteinase expression, migration, nanoparticles, physics, wounds, Zinc dependent enzymes

we examined the effect of seven polymer modifiers (2-amino-3-guanidinopropionic acid, arginine, camitine, citrulline, creatine, 3-guanidino propionic add, and N-w-nitro-L-arginine) on MMP-13 activity. MMP-13 is a collagenase that is present in chronic wounds and is zinc dependent. Our results showed that these polymer modifiers were able to inhibit MMP-13 activity to varying degrees. The mechanism of inhibition appears to be binding zinc to the modifiers. (C) 2015 Elsevier B.V. All rights reserved.

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Short TitleSurf. Sci.
Alternate JournalSurf. Sci.