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Improving selective targeting to macrophage subpopulations through modifying liposomes with arginine based materials

TitleImproving selective targeting to macrophage subpopulations through modifying liposomes with arginine based materials
Publication TypeJournal Article
Year of Publication2016
AuthorsMa, L, Bygd, HC, Bratlie, KM
JournalIntegrative Biology
Volume9
Pagination58-67
Date Published11
Type of ArticleArticle
ISBN Number1757-9694
Accession NumberWOS:000394577500004
Keywordsactivation, cell biology, delivery, doxorubicin, homeostasis, in-vitro, internalization pathways, nanoparticles, polarization, tumor-associated macrophages, vivo
Abstract

eukin-4 (IL-4) to induce M1- or M2-like phenotypes. Naive macrophages were also studied. Most modified liposomes enhanced the cytotoxicity of doxorubicin compared to unmodified liposomes. Macrophage phenotype was also observed to influence the cytotoxicity of doxorubicin entrapped in modified liposomes, with some samples enhancing the cytotoxicity in LPS stimulated macrophages and some enhancing toxicity in IL-4 stimulated cells.

DOI10.1039/c6ib00133e
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Short TitleIntegr. Biol.
Alternate JournalIntegr. Biol.