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Fluorescence Spectroscopy of the Retina for the Screening of Bovine Spongiform Encephalopathy

TitleFluorescence Spectroscopy of the Retina for the Screening of Bovine Spongiform Encephalopathy
Publication TypeJournal Article
Year of Publication2016
AuthorsBhattacharjee, U, Graham, C, Czub, S, Dudas, S, Rasmussen, MA, Casey, TA, Petrich, JW
JournalJournal of Agricultural and Food Chemistry
Date Published01
Type of ArticleArticle
ISBN Number0021-8561
Accession NumberWOS:000368322900041
Keywordsage-related-changes, bovine spongiform, central-nervous-system, creutzfeldt-jakob-disease, encephalopathy, fluorescence spectroscopy, in-vivo measurement, lipid, lipofuscin, lipofuscin granules, macular degeneration, oxidation, pigment epithelium, poultry meat, real-time detection, retinal scan, transmissible spongiform encephalopathy

Transmissible spongiform encephalopathies (TSE) are progressive, neurodegenerative disorders, of which bovine spongiform encephalopathy (BSE) is of special concern because it is infectious and debilitating to humans. The possibility of using fluorescence spectroscopy to screen for BSE in cattle was explored. Fluorescence spectra from the retinas of experimentally infected ESE-positive cattle with clinical disease were compared with those from both sham-inoculated and non-inoculated BSE-negative cattle. The distinct intensity difference of about 4-10-fold between the spectra of the BSE-positive and the BSE-negative (sham-inoculated and non-inoculated) eyes suggests the basis for a means of developing a rapid, noninvasive examination of BSE in particular and TSEs in general.

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