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Ferromagnetic Gd5Si4 Nanoparticles as T2 Contrast Agents for Magnetic Resonance Imaging

TitleFerromagnetic Gd5Si4 Nanoparticles as T2 Contrast Agents for Magnetic Resonance Imaging
Publication TypeJournal Article
Year of Publication2017
AuthorsEl-Gendy, HA, Harstad, SM, Vijayaragavan, V, Gupta, S, Pecharsky, VK, Zweit, J, Hadimani, RL
JournalIeee Magnetics Letters
Volume8
Pagination1507504
Date Published08
Type of ArticleArticle
ISBN Number1949-307X
Accession NumberWOS:000407456800001
KeywordsBiomagnetics, clinical-application, Contrast agents, Engineering, gadoliniumsilicide, Magnetic, magnetic resonance imaging, mri, nanoparticles, physics, superparamagnetic iron-oxide
Abstract

Room temperature ferromagnetic Gd5Si4 nanoparticles were synthesized using arc-melting and high-energy ball milling. We demonstrate that these particles can be used as potential T2 contrast agents for magnetic resonance imaging (MRI). The ball-milled Gd5Si4 nanostructured material shows a ferromagnetic-to-paramagnetic transition at 320 K, revealing long-range magnetic order of the Gd5Si4 phase. Echo time was measured in a 7 T magnetic resonance imaging system and shows significant reduction compared to that reported for superparamagnetic iron oxide nanoparticles. These results show the potential of Gd5Si4 ferromagnetic nanoparticles as T2 contrast agents for MRI.

DOI10.1109/lmag.2017.2728503
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