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Electrical Differentiation of Mesenchymal Stem Cells into Schwann-Cell-Like Phenotypes Using Inkjet-Printed Graphene Circuits

TitleElectrical Differentiation of Mesenchymal Stem Cells into Schwann-Cell-Like Phenotypes Using Inkjet-Printed Graphene Circuits
Publication TypeJournal Article
Year of Publication2017
AuthorsDas, SR, Uz, M, Ding, S, Lentner, MT, Hondred, JA, Cargill, AA, Sakaguchi, DS, Mallapragada, S, Claussen, JC
JournalAdvanced Healthcare Materials
Volume6
Pagination1601087
Date Published04
Type of ArticleArticle
ISBN Number2192-2640
Accession NumberWOS:000399719900006
Keywordscells, differentiation, Engineering, expression, fields, induce neural differentiation, lineage commitment, marrow, Materials Science, neuronal differentiation, osteogenic, sciatic-nerve regeneration, stimulation, stromal, Technology - Other Topics
Abstract

1 k Omega/sq) via a postprint pulse-laser annealing process. MSCs immobilized on the graphene printed IDEs and electrically stimulated/ treated (etMSCs) display significant enhanced cellular differentiation and paracrine activity above conventional chemical treatment strategies [approximate to 85% of the etMSCs differentiated into SC-like phenotypes with approximate to 80 ng mL(-1) of nerve growth factor (NGF) secretion vs. 75% and approximate to 55 ng mL(-1) for chemically treated MSCs (ctMSCs)]. These results help pave the way for in vivo peripheral nerve regeneration where the flexible graphene electrodes could conform to the injury site and provide intimate electrical simulation for nerve cell regrowth.

DOI10.1002/adhm.201601087
Custom 1

Not AL

Short TitleAdv. Healthc. Mater.
Alternate JournalAdv. Healthc. Mater.