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Efficient synthesis of fluorescent rosamines: multifunctional platforms for cellular imaging

TitleEfficient synthesis of fluorescent rosamines: multifunctional platforms for cellular imaging
Publication TypeJournal Article
Year of Publication2014
AuthorsKraus, G, Guney, T, Kempema, A, Hyman, JM, Parvin, B
JournalTetrahedron Letters
Volume55
Pagination1549-1551
Date Published02
Type of ArticleArticle
ISBN Number0040-4039
Accession NumberWOS:000332434000009
KeywordsAcidic hydrolysis, Benzophenone imine, cells, Fluorescent, Organolithium, probe, Rosamine, Xanthone
Abstract

Substituted rosamines are efficiently prepared through a new organometallic addition to an iminesubstituted xanthone as a novel primary amine equivalent. The synthesis reduces the number of synthetic steps to the targeted rosamines, for convenient and facile access to potential libraries of rosamine dyes. The prepared rosamine derivatives represent unique multifunctional platforms that possess radiolabeling capability and fluorescence. Rosamines have (i) useful non-specific binding properties in mammalian cells and plant root hair, and (ii) positive uptake or binding properties in microbial systems. (C) 2014 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetlet.2014.01.067
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