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Altering in vivo macrophage responses with modified polymer properties

TitleAltering in vivo macrophage responses with modified polymer properties
Publication TypeJournal Article
Year of Publication2015
AuthorsBygd, HC, Forsmark, KD, Bratlie, KM
JournalBiomaterials
Volume56
Pagination187-197
Date Published07
Type of ArticleArticle
ISBN Number0142-9612
Accession NumberWOS:000355041600019
Keywordsactivation, alternative, biocompatibility, Biomedical applications, cancer, cathepsin-d, granules, implanted biomaterials, In vivo test, inflammatory responses, Macrophage phenotype, necrosis-factor, neutrophil, polarization, polymer, properties, protein adsorption, Surface modification, tumor-associated macrophages
Abstract

Macrophage reprogramming has long been the focus of research in disease therapeutics and biomaterial implantation. With different chemical and physical properties of materials playing a role in macrophage polarization, it is important to investigate and categorize the activation effects of material parameters both in vitro and in vivo. In this study, we have investigated the effects of material surface chemistry on in vivo polarization of macrophages. The library of materials used here include poly(N-iso-propylacrylamide-co-acrylic acid) (p(NIPAm-co-AAc)) nanoparticles (similar to 600 nm) modified with various functional groups. This study also focuses on the development of a quantitative structure activity relationship method (QSAR) as a predictive tool for determining the macrophage polarization in response to particular biomaterial surface chemistries. Here, we successfully use in vivo imaging and histological analysis to identify the macrophage response and activation. We demonstrate the ability to induce a spectrum of macrophage phenotypes with a change in material functionality as well as identify certain material parameters that seem to correlate with each phenotype. This suggests the potential to develop materials for a variety of applications and predict the outcome of macrophage activation in response to new surface chemistries. (C) 2015 Elsevier Ltd. All rights reserved.

DOI10.1016/j.biomaterials.2015.03.042
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