This highly interdisciplinary project seeks to develop approaches to facilitate repair and regeneration of the damaged nervous system. We will use a combination of biomaterials in the form of polymer conduits and/or scaffolds, adult stem cells seeded on the biomaterials, and use of physical, chemical, biological and/or electrical cues to orient cell growth, control stem cell differentiation and facilitate neuroregeneration using in vitro models.
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Aptamers are small nucleic acids that can be used in medical applications and as means of detecting specific molecules. This is because these nucleic acids behave like antibodies and recognize specific molecules. Aptamers can also function in the body either outside or inside cells. We are developing the use of aptamers to increase the effectiveness of anticancer and other drugs for medical treatment and to image cells like stem cells. We are also using aptamers to develop new monitoring methods for drugs of abuse and to monitor toxins in the environment.
There are two areas of organic electronics that are of interest through modeling and simulation. The first area involves organic light emitting diodes (OLEDs), and a critical problem is that that a large fraction of light -more than 80%- is trapped and lost inside the high refractive index layers within the OLED. We will consider various ways to design textured internal and textured external surfaces of the OLEDS that can extract this trapped light. We will use rigorous electromagnetic and photonic simulations for the modeling.
Miniature microbial fuel cells have recently drawn lots of attention as portable power generation devices due to their short startup time and environmentally-friendly process which could be used for powering small integrated biosensors. We aim to design and fabricate a microbial fuel cell in a microfluidic platform and integrate it with lab-on-a-chip devices and MEMS. Our approach is to make the device using polydimethylsi-loxane with a chamber volume of as low as 4 Î¼L, and ultra-thin catalyst-electrodes based on functional soft materials.
Bioelectrochemical systems (BES) have recently emerged as a central technology in an attempt to produce electricity. In a BES, bacteria interact with electrodes using electrons, which are either removed or supplied through an electrical circuit. The most recognized type of BES is microbial fuel cells (MFCs), in which useful power is generated from electron donors as, for example, present in wastewater.
The research goal of this project is to examine the impact of microstructure â€“material on the stochastic fracture process. The microstructure phases and grain size distributions provide a spatial basis for understanding mechanics material damage modeling. The project will work with characterizing microstructures and determine a class of distributions using metallographic examination and crystallographic data. The project will involve sample preparation, measurements and examination of stochastic processes in microstructure.
September 23-27, 2013 - Advanced Bloodstain Pattern Analysis Workshop
Northeast Forensic Training Center, Bethlehem, PA