Scientific and Technical Information (STI)

Scientific and Technical Information

Dr. Marit Nilsen-Hamilton

Ames Laboratory Associate and Professor, Iowa State University
Address
3206 Molecular Biology
Iowa State University
Ames, IA 50011
Phone 515-294-9996
Fax 515-294-0453
Email marit@iastate.edu

Research Interests


        Project Affiliations:
        Bioinspired Materials
        Imaging Gene Expression

(Chronologically most recent on top)Publications with the Ames Laboratory

2007
Prozorov T; Palo P; Wang L; Nilsen-Hamilton M; Jones D; Orr D; Mallapragada S K; Narasimhan B; Canfield P C; Prozorov R . 2007. Cobalt ferrite nanocrystals: Out-performing magnetotactic bacteria. Acs Nano. 1:228-233. abstract
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Prozorov T; Mallapragada S K; Narasimhan B; Wang L J; Palo P; Nilsen-Hamilton M; Williams T J; Bazylinski D A; Prozorov R; Canfield P C . 2007. Protein-mediated synthesis of uniform superparamagnetic magnetite nanocrystals. Advanced Functional Materials. 17:951-957. abstract
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Personnel

Overview

We are developing apatmers to use as cellular receptors for imaging gene expression in a technology termed Gene expression measurement by Revealed Aptmaer Based Imaging Technology (GRABIT) that includes tow approaches using aptamers to image gene expression:  (i) Intracellular Multiaptamer Genetic tags (IMAGEtags), which are aptamer expressing reporter genes, and (ii) Targeted Reversibly Attenuated Probes (TRAPS), which are allosterically regulated aptamer probes.  These RNA probes are being developed for imaging in plants and bacterial species.  

 

This research is supported by the U.S. Department of Energy, Office of Biological and Environmental Research through the Ames Laboratory.  The Ames Laboratory is operated for the U.S. Department of Energy by Iowa State University under Contract No. DE-AC02-07CH11358.

Publications

2013
Ilgu M; Wang T J; Lamm M H; Nilsen-Hamilton M . 2013. Investigating the malleability of RNA aptamers. Methods. 63:178-187. abstract
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2012
Nath Sangeeta; Spencer Virginia A; Han Ju; Chang Hang; Zhang Kai; Fontenay Gerald V; Anderson Charles; Hyman Joel M; Nilsen-Hamilton M; Chang Young-Tae; Parvin Bahram . 2012. Identification of Fluorescent Compounds with Non-Specific Binding Property via High Throughput Live Cell Microscopy. PLoS ONE. 7:e28802. abstract
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2009
Wang T J; Hoy J A; Lamm M H; Nilsen-Hamilton M . 2009. Computational and Experimental Analyses Converge to Reveal a Coherent Yet Malleable Aptamer Structure That Controls Chemical Reactivity. Journal of the American Chemical Society. 131:14747-14755. abstract
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Dr. Oleg Pestovsky

Assistant Scientist III
Address
26 Spedding Hall
The Ames Laboratory
Ames, IA 50011-3020
Phone 515-294-5826
Fax 515-294-4709
Email pvp@ameslab.gov

Research Interests

Mechanistic investigation of inorganic, organometallic, and bioinorganic reactions. Activation of molecular oxygen, nitrogen, and nitrogen monoxide in catalytic transformations. Investigation of reactive intermediates in catalytic transformations, such as high-valent transition metal oxo, superoxo, and hydroperoxo complexes. Stopped-flow and laser flash photolysis for generation of free radicals and reactive transition metal-based transients.


        Project Affiliations:

(Chronologically most recent on top)Education

  • Ph.D., Inorganic Chemistry, Iowa State University.
  • B.S., Chemistry, Higher Chemical College of the Russian Academy of Sciences, Moscow, Russia.

(Chronologically most recent on top)Professional Appointments

  • 2004-present   Assistant Scientist, Ames Laboratory.
  • 2001-2004       Postdoctoral Research Associate, Iowa State University.

(Chronologically most recent on top)Honors & Awards

  • 2008 “Identification and Characterization of Aqueous Iron(IV) Complex”, Chemistry Department, Iowa State University (Invited Talk).
  • 2006 “Identification and Characterization of Aqueous Ferryl(IV)”, ACS National Meeting, San Francisco (Invited Talk).
  • 2004 “Catalytic Oxidations by Molecular Oxygen”, Brookhaven National Laboratory (Invited Talk)

(Chronologically most recent on top)Publications with the Ames Laboratory

2013
Bakac A; Pestovsky O; Durfey B L; Kristian K E . 2013. Kinetics and thermodynamics of nitric oxide binding to transition metal complexes. Relationship to dioxygen binding. Chemical Science. 4:2185-2192. abstract
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2012
Jana B; Hovey M; Ellern A; Pestovsky O; Sadow A D; Bakac A . 2012. Unusual structural motif in a zwitterionic Fe(II) complex of a tetradentate phosphine. Dalton Transactions. 41:12781-12785. abstract
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Carraher J M; Pestovsky O; Bakac A . 2012. Transition metal ion-assisted photochemical generation of alkyl halides and hydrocarbons from carboxylic acids. Dalton Transactions. 41:5974-5980. abstract
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Bataineh H; Pestovsky O; Bakac A . 2012. pH-induced mechanistic changeover from hydroxyl radicals to iron(IV) in the Fenton reaction. Chemical Science. 3:1594-1599. abstract
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2011
Jana B; Ellern A; Pestovsky O; Sadow A; Bakac A . 2011. Synthesis of Monomeric Fe(II) and Ru(II) Complexes of Tetradentate Phosphines. Inorganic Chemistry. 50:3010-3016. abstract
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Pestovsky O; Veysey S W; Bakac A . 2011. Kinetics and Mechanism of Hydrogen-Atom Abstraction from Rhodium Hydrides by Alkyl Radicals in Aqueous Solutions. Chemistry-A European Journal. 17:4518-4522. abstract
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2010
Jee J E; Pestovsky O; Bakac A . 2010. Preparation and characterization of manganese(IV) in aqueous acetic acid. Dalton Transactions. 39:11636-11642. abstract
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Jee J E; Pestovsky O; Hidayat I; Szajna-Fuller E; Bakac A . 2010. Mechanism of oxidation of alkyl and superoxo complexes of chromium(III) by aquamanganese(III) ions. Journal of Coordination Chemistry. 63:2578-2585. abstract
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2008
Pestovsky O; Harrata K A; Bakac A . 2008. Evidence for a tetraoxo intermediate in a reaction between a superoxometal complex and acylperoxyl radicals. Journal of Physical Chemistry A. 112:7758-7760. abstract
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2007
Furczon M; Pestovsky O; Bakac A . 2007. Kinetics of dissociation of molecular oxygen from a superoxorhodium(III) complex and reactivity of a macrocyclic rhodium(II) ion. Inorganic Chemistry. 46:11461-11466. abstract
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Lessons Learned

Ames Laboratory Lessons Learned

Red Alerts - Urgent, Actual Event, public impact, fatality, violation of State or Federal law with significant penalties.

Yellow Alerts - Caution, Potential Event, injury, temporary/partial disability, significant loss of work time/productivity, violation of State or Federal law with minor penalties.

Personnel

Overview

Magnetic materials are essential in electrical generators using wind, water, and even carbon based fuels.  Magnets are also essential in motors for vehicles and other electro-mechanical devices, including levitators.  A long-term goal of this project is the discovery of new magnetic materials with enhanced properties relevant for higher efficiency in energy production and utilization, and the creation of alternatives for current materials that may face supply issues.  This effort will be a prototype for future materials discovery campaigns focused on other properties. It will be accelerated by the development and integration of computational tools and strategies for materials discovery tightly coupled to a strong experimental synthesis and characterization effort.  The materials palette used to develop new magnetic materials will include d and f-electron elements and also volatile light elements, allowing us to reach into less-explored material composition spaces.  The materials informatics strategies, theoretical algorithms, and computational tools implemented will be generic, so that data base knowledge accumulated and searching algorithms developed will serve as a foundation for materials discovery efforts aimed at other strategic properties.   These tools will also be used in the pursuit of fundamental science questions in magnetism.

Highlights

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Publications

2013
Khan S N; Alam A; Johnson D D . 2013. Low-energy planar magnetic defects in BaFe2As2: Nanotwins, twins, antiphase, and domain boundaries. Physical Review B. 88:184515. abstract
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Sun R S; Johnson D D . 2013. Stability maps to predict anomalous ductility in B2 materials. Physical Review B. 87:104107. abstract
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2012
Kim M G; Lamsal J; Heitmann T W; Tucker G S; Pratt D K; Khan S N; Lee Y B; Alam A; Thaler A; Ni N; Ran S; Bud'ko S L; Marty K J; Lumsden M D; Canfield P C; Harmon B N; Johnson D D; Kreyssig A; McQueeney R J; Goldman A I . 2012. Effects of Transition Metal Substitutions on the Incommensurability and Spin Fluctuations in BaFe2As2 by Elastic and Inelastic Neutron Scattering. Physical Review Letters. 109:167003. abstract
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Bao L H; He L; Meyer N; Kou X F; Zhang P; Chen Z G; Fedorov A V; Zou J; Riedemann T M; Lograsso T A; Wang K L; Tuttle G; Xiu F X . 2012. Weak Anti-localization and Quantum Oscillations of Surface States in Topological Insulator Bi2Se2Te. Scientific Reports. 2:726. abstract
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Chouhan R K; Alam A; Ghosh S; Mookerjee A . 2012. Ab initio study of the phonon spectrum, entropy and lattice heat capacity of disordered Re-W alloys. Journal of Physics-Condensed Matter. 24:375401. abstract
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Jiang R; Wang L L; Huang M L; Dhaka R S; Johnson D D; Lograsso T A; Kaminski A . 2012. Reversible tuning of the surface state in a pseudobinary Bi-2(Te-Se)(3) topological insulator. Physical Review B. 86:085112. abstract
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Alam A; Johnson D D . 2012. Structural properties and relative stability of (meta)stable ordered, partially ordered, and disordered Al-Li alloy phases. Physical Review B. 85:144202. abstract
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2011
Alam A; Wilson B G; Johnson D D . 2011. Accurate and fast numerical solution of Poisson's equation for arbitrary, space-filling Voronoi polyhedra: Near-field corrections revisited. Physical Review B. 84:205106. abstract
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Yan J-Q; Xing Q; Jensen B; Xu H; Dennis K W; McCallum R W; Lograsso T A . 2011. Contamination from Magnetic Starting Materials in Flux-grown Single Crystals of RFeAsO Superconductors. Physical Review B. 84:012501. abstract
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Wang L L; Johnson D D . 2011. Ternary tetradymite compounds as topological insulators. Physical Review B. 83:241309. abstract
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Personnel

Overview

Biological templates for metallization will be produced based on natural structures of DNA combined with interacting proteins to stabilize the structures. The proteins will be modified to attract metal ions such as gold or silver. In these initial studies to establish templates we propose to produce circular templates with a single gap (split rings). Several approaches will be used to produce these templates, which rely on the ability of DNA to circularize, the abilities of certain proteins to bind DNA, the specificity of certain proteins for particular DNA sequences, the modularity of protein structure and the ability to construct fusion proteins with DNA binding domains. The base structures for the production of circles will be DNA that is either single or double stranded. The sequences of the base DNA structures will be defined according to the proteins that will be used to decorate them. The purpose of the proteins will be to:

  • stabilize the DNA structure
  • provide a template for the attraction of metal ions to the structure

A variety of strategies will be used with different DNA binding proteins and different metal chelating options to optimize

  • shape
  • metal accumulation

Metallization will be achieved by electroless deposition. Decisions of which parameters to optimize will be informed by the results of the theoretical studies and metallization studies.

Publications

Personnel

Overview

To address the need for new computational methods for treating correlated materials and develop a first principle study of superconductivity, a novel approach will be developed, built on a nonperturbative many-body method, based on a combination of dynamical mean field and GW theories, which can yield material-specific predictions and interpretation of properties of solids. Our objectives are to implement this approach using the high-performance, all-electron, full-potential, relativistic linear augmented plane. The wave method will be applied to this powerful many-body tool by tackling frontier problems of material science such as computational design of novel based superconductors. Parts of this project that will be pursued by the Ames Laboratory Principal Investigators contain:

  • The development of computational tools to determine the dynamical pairing interaction in the pnictides.
  • The investigation of a first principle approach to superconductivity using a dynamic pairing interaction.
  • The development of a Gutzwiller-based density functional formalism for the magneto-elastic interaction in the iron arsenides.

Highlights

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Publications

Personnel

Overview

The purpose of this project is to develop the first generation of advanced thin film coatings for high contact stress applications. The results will facilitate domestic energy production through reduced cost of coal gasification, improve fuel efficiency, and lead to novel energy solutions through successful development of materials that are exposed to extreme operating conditions. New research into advanced, nanocomposite materials with an order of magnitude better wear resistance than current offerings has shown great promise. Scale-up efforts will focus on transitioning laboratory-scale, bulk nanocomposite materials research to coated components that perform in environments where all previous coatings have failed. A primary objective will be to transition the superior performance of the bulk, laboratory-scale materials into a thin-film coating that will sustain a target pressure-velocity (PV) product of at least 70,000 MPa-m/s.

Publications

2013
Gaballa O; Ball J H; Cook B; Peters J S; Russell A . 2013. Properties of AlMgB14 hot pressed with additions of ZrB2 and HfB2. Powder Technology. 235:968-974. abstract
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2011
Gaballa O; Cook B; Russell A . 2011. Formation, densification, and selected mechanical properties of hot pressed Al(4)SiC(4), Al(4)SiC(4) with 30 vol.% WC, and Al(4)SiC(4) with 30 vol.% TiC. Ceramics International. 37:3117-3121. abstract
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Li D Y; Chen Q; Cook B . 2011. A further simulation study on the dual role of porosity in solid-particle erosion of materials. Wear. 271:1325-1330. abstract
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Higdon C; Cook B; Harringa J; Russell A; Goldsmith J; Qu J; Blau P . 2011. Friction and wear mechanisms in AlMgB(14)-TiB(2) nanocoatings. Wear. 271:2111-2115. abstract
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Cook B A; Peters J S; Harringa J L; Russell A M . 2011. Enhanced wear resistance in AlMgB(14)-TiB(2) composites. Wear. 271:640-646. abstract
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2010
Cook B A; Harringa J L; Anderegg J; Russell A M; Qu J; Blau P J; Higdon C; Elmoursi A A . 2010. Analysis of wear mechanisms in low-friction AlMgB14-TiB2 coatings. Surface & Coatings Technology. 205:2296-2301. abstract
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