A Linear Ion Trap Mass Spectrometer with Versatile Control and Data Acquisition for Ion/Ion Reactions

TitleA Linear Ion Trap Mass Spectrometer with Versatile Control and Data Acquisition for Ion/Ion Reactions
Publication TypeJournal Article
Year of Publication2008
AuthorsSoyk MW, Zhao Q, Houk RS, Badman ER
Journal TitleJournal of the American Society for Mass Spectrometry
Volume19
Pages1821-1831
Date Published12
ISBN Number1044-0305
Accession NumberISI:000261808900014
KeywordsANIONS, cations, ejection, electron-transfer dissociation, esi, fields, ionization, of-flight system, parking, performance
Abstract

A linear ion trap (LIT) with electrospray ionization (ESI) for top-down protein analysis has been constructed. An independent atmospheric sampling glow discharge ionization (ASGDI) Source produces reagent ions for ion/ion reactions. The device is also meant to enable a wide variety of ion/ion reaction Studies. To reduce the instrument's complexity and make it available for wide dissemination, only a few simple electronics components were Custom built. The instrument functions as both a reaction vessel for gas-phase ion/ion reactions and a mass spectrometer using mass-selective axial ejection. Initial results demonstrate trapping efficiency of 70% to 90% and the ability to perform proton transfer reactions on intact protein ions, including dual polarity storage reactions, transmission mode reactions, and ion parking. (J Am Soc Mass Spectrom 2008, 19, 1821-1831) (c) 2008 Published by Elsevier Inc. on behalf of American Society for Mass Spectrometry

URL<Go to ISI>://000261808900014
DOI10.1016/J.Jasms.2008.08.020