Engineering 3D biomimetic scaffolds that incorporate both biochemical and mechanical properties required for cell culturing is critical for many biotechnology applications. Hydrogel-based scaffolds are widely used due to their biocompatibility, tunable biochemical properties, and tissue-like water content. In contrast to hydrogels, microfibers have high mechanical strength and are used as the building blocks to create highly porous scaffolds.
At the Hashemi Lab, we are interested in exploring different fabrication processes for the development of the microfibers. We will study the effect of fabrication parameters such as ejection rate, temperature, and time of pre-fixation on microfiber properties. The resulting scaffold morphology will be characterized using scanning electron microscopy and compression test.
Mentor: Nastaran Hashemi, assistant professor, Mechanical Engineering, Iowa State University