Tuning the Kinetics of Cadherin Adhesion

TitleTuning the Kinetics of Cadherin Adhesion
Publication TypeJournal Article
Year of Publication2013
AuthorsSivasankar S
Journal TitleJournal of Investigative Dermatology
Volume133
Pages2318-2323
Date Published10
Type of ArticleReview
ISBN Number0022-202X
Accession NumberWOS:000324899100007
Keywordsadherens, alpha-catenin, catch bonds, cell-cell-adhesion, classical cadherins, crystal-structure, extracellular domains, JUNCTIONS, mediated adhesions, structural basis, tissue morphogenesis
Abstract

Cadherins are Ca(2+-)dependent cell-cell adhesion proteins that maintain the structural integrity of the epidermis; their principle function is to resist mechanical force. This review summarizes the biophysical mechanisms by which classical cadherins tune adhesion and withstand mechanical stress. We first relate the structure of classical cadherins to their equilibrium binding properties. We then review the role of mechanical perturbations in tuning the kinetics of cadherin adhesion. In particular, we highlight recent studies that show that cadherins form three types of adhesive bonds: catch bonds, which become longer lived and lock in the presence of tensile force; slip bonds, which become shorter lived when pulled; and ideal bonds, which are insensitive to tugging.

URL<Go to ISI>://WOS:000324899100007
DOI10.1038/jid.2013.229