Synthesis and functionalization of a mesoporous silica nanoparticle based on the sol-gel process and applications in controlled release

TitleSynthesis and functionalization of a mesoporous silica nanoparticle based on the sol-gel process and applications in controlled release
Publication TypeJournal Article
Year of Publication2007
AuthorsTrewyn BG, Slowing II, Giri S, Chen HT, Lin VSY
Journal TitleAccounts of Chemical Research
Volume40
Pages846-853
Date PublishedSep
Type of ArticleReview
ISBN Number0001-4842
Accession NumberISI:000249610500015
Keywordscells, delivery-system, molecular-sieves, MORPHOLOGY, NEUROTRANSMITTERS, organic functionalization, responsive controlled-release
Abstract

Mesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity. It is shown that these particles possess external and internal surfaces that can be selectively functionalized with multiple organic and inorganic groups. On the basis of these characteristics, the biocompatibility of silica, and their efficient uptake by mammalian cells, MSNs are proposed as the basis of nanodevices for the controlled release of drugs and genes into living cells.

DOI10.1021/ar600032u
Alternate JournalAccounts Chem. Res.