Mesoporous silica nanoparticles for drug delivery and biosensing applications

TitleMesoporous silica nanoparticles for drug delivery and biosensing applications
Publication TypeJournal Article
Year of Publication2007
AuthorsSlowing II, Trewyn BG, Giri S, Lin VSY
Journal TitleAdvanced Functional Materials
Volume17
Pages1225-1236
Date PublishedMay
Type of ArticleArticle
ISBN Number1616-301X
Accession NumberISI:000246861800001
Keywordscells, delivery, gene, NANOCAPSULES, NEUROTRANSMITTERS, organic functionalization, particles, responsive controlled-release, SHELL, SOL-GEL, system
Abstract

Recent advancements in morphology control and surface functionalization of mesoporous silica nanoparticles (MSNs) have enhanced the biocompatibility of these materials with high surface areas and pore volumes. Several recent reports have demonstrated that the MSNs can be efficiently internalized by animal and plant cells. The functionalization of MSNs with organic moieties or other nanostructures brings controlled release and molecular recognition capabilities to these mesoporous materials for drug/gene delivery and sensing applications, respectively. Herein, we review recent research progress on the design of functional MSN materials with various mechanisms of controlled release, along with the ability to achieve zero release in the absence of stimuli, and the introduction of new characteristics to enable the use of nonselective molecules as screens for the construction of highly selective sensor systems.

DOI10.1002/adfm.200601191
Alternate JournalAdv. Funct. Mater.