Capped mesoporous silica nanoparticles as stimuli-responsive controlled release systems for intracellular drug/gene delivery

TitleCapped mesoporous silica nanoparticles as stimuli-responsive controlled release systems for intracellular drug/gene delivery
Publication TypeJournal Article
Year of Publication2010
AuthorsZhao YN, Vivero-Escoto JL, Slowing II, Trewyn BC, Lin VSY
Journal TitleExpert Opinion on Drug Delivery
Volume7
Pages1013-1029
Date Published09
ISBN Number1742-5247
Accession NumberISI:000282072500002
Keywordsbiocompatibility, capped mesoporous silica nanoparticles, drug-delivery, guest molecules, intracellular drug/gene delivery, MESENCHYMAL STEM-CELLS, nanoparticle endocytosis, operated mechanized nanoparticles, stimuli-responsive controlled release systems
Abstract

Importance of the field: The incorporation of stimuli-responsive properties into nanostructured systems has recently attracted significant attention in the research of intracellular drug/gene delivery. In particular, numerous surface-functionalized, end-capped mesoporous silica nanoparticle (MSN) materials have been designed as efficient stimuli-responsive controlled release systems with the advantageous 'zero premature release' property.Areas covered in this review: Herein, the most recent research progress on the design of biocompatible, capped MSN materials for stimuli-responsive intracellular controlled release of therapeutics and genes is reviewed. A series of hard and soft caps for drug encapsulation and a variety of internal and external stimuli for controlled release of different cargoes are summarized. Recent investigations on the biocompatibility of MSN both in vitro and in vivo are also discussed.What the reader will gain: The reader will gain an understanding of the challenges for the future exploration of biocompatible stimuli-responsive MSN devices.Take home message: With a better understanding of the unique features of capped MSN and its behaviors in biological environment, these multifunctional materials will find a wide variety of applications in the field of drug/gene delivery.

URL<Go to ISI>://000282072500002
DOI10.1517/17425247.2010.498816