Biocompatible mesoporous silica nanoparticles with different morphologies for animal cell membrane, penetration

TitleBiocompatible mesoporous silica nanoparticles with different morphologies for animal cell membrane, penetration
Publication TypeJournal Article
Year of Publication2008
AuthorsTrewyn BG, Nieweg JA, Zhao Y, Lin VSY
Journal TitleChemical Engineering Journal
Volume137
Pages23-29
Date PublishedMar
Type of ArticleArticle
ISBN Number1385-8947
Accession NumberISI:000254023900004
Keywordscell, CONDENSATION, delivery-system, EFFICIENT, endocytosis, functionalization, HUMAN CANCER-CELLS, intracellular delivery, mcm-41, membrane, mesoporous silica nanoparticle, MOL, nanosphere, nanotube, responsive controlled-release
Abstract

Two MCM-41 type, fluorescein-labeled mesoporous silica nanomaterials (MSNs) consisting of spherical and tube-shaped particles were synthesized and characterized. Both materials have hexagonally arranged mesopores with high surface area (>950 m(2)/g) and a narrow distribution of pore diameters. The cellular uptake efficiency and kinetics of both MSNs were measured in a cancer cell line (CHO) and a noncancerous cell line (fibroblasts) by flow cytometry and fluorescence confocal microscopy. The correlation between the particle morphology and aggregation of MSNs to the effectiveness of cellular uptake was investigated. We envision that our study on the morphology dependent endocytosis of MSNs would lead to future developments of efficient transmembrane nanodevices for intracellular sensing and gene/drug delivery. (C) 2007 Elsevier B.V. All rights reserved.

DOI10.1016/j.cej.2007.09.045
Alternate JournalChem. Eng. J.