Chemical Analysis of Nanodomains

Personnel

Project Leader(s):
Emily Smith

Principal Investigators:
Ning Fang, Jacob Petrich, Emily Smith

Overview

We seek to understand the basic principles that underlie energy-relevant chemical separations; develop analytical methods to improve the sensitivity, reliability, and productivity of analytical determinations; and to develop new approaches to analysis. Our research emphasizes instrumentation and technique development highly relevant to the main focus areas of the Separation and Analysis activities of the Division of Chemical Science, Geoscience and Biosciences within the DOE Office of Basic Energy Sciences.  

The goal of this research is to develop the next generation of imaging tools and methodologies for the analysis of phenomena that occur at nanometer length scales and picosecond time scales. The developed instrumentation and methodology will be applied to model systems of interest to the DOE mission, where fundamental insight can be gained with the high spatial and temporal resolution afforded by our developed methods: chemical reac tions in heterogeneous silica supported catalysts; the organization and dynamics of mixed model lipid bilayers and cell membranes; chromatographic interactions; and heterogeneous enzyme reactions. The methods we propose to develop are:

1. High resolution total internal reflection (TIR) Raman microspectroscopy and imaging
2. Sub-diffraction limited imaging, including differential interference contrast (DIC) microscopy, variable-angle evanescent-field (EFM) microscopy, and time-resolved stimulated emission depletion (STED) microscopy
3. Novel single molecule spectroscopies

 

This research is supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences, and Biosciences through the Ames Laboratory.  The Ames Laboratory is operated for the U.S. Department of Energy by Iowa State University under Contract No. DE-AC02-07CH11358.

Publications

2013
Marchuk K; Ha J W; Fang N . 2013. Three-Dimensional High-Resolution Rotational Tracking with Superlocalization Reveals Conformations of Surface-Bound Anisotropic Nanoparticles. Nano Letters. 13:1245-1250. abstract
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Marchuk K; Ha J W; Fang N . 2013. Three-Dimensional High-Resolution Rotational Tracking with Superlocalization Reveals Conformations of Surface-Bound Anisotropic Nanoparticles. Nano Letters. 13:1245-1250. abstract
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Gu Y; Wang G F; Fang N . 2013. Simultaneous Single-Particle Superlocalization and Rotational Tracking. ACS Nano. 7:1658-1665. abstract
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Lesoine M D; Bhattacharjee U; Guo Y J; Vela J; Petrich J W; Smith E A . 2013. Subdiffraction, Luminescence-Depletion Imaging of Isolated, Giant, CdSe/CdS Nanocrystal Quantum Dots. Journal of Physical Chemistry C. 117:3662-3667. abstract
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2012
Mckee K J; Meyer M W; Smith E A . 2012. Plasmon Waveguide Resonance Raman Spectroscopy. Analytical Chemistry. 84:9049-9055. abstract
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Meyer M W; Mckee K J; Nguyen V H T; Smith E A . 2012. Scanning Angle Plasmon Waveguide Resonance Raman Spectroscopy for the Analysis of Thin Polystyrene Films. Journal of Physical Chemistry C. 116:24987-24992. abstract
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Ma C B; Chen H C; Han R; He H L; Zeng W M . 2012. Fluorescence detection of adenosine triphosphate using smart probe. Analytical Biochemistry. 429:8-10. abstract
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Ma C B; Xia K; Chen H C; Zeng W M; Han R; Tang J H . 2012. Label-free highly sensitive detection of telomerase activity in cancer cell by chemiluminescence imaging. Molecular and Cellular Probes. 26:212-214. abstract
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Han R; Wang G F; Qi S D; Ma C B; Yeung E S . 2012. Electrophoretic Migration and Axial Diffusion of Individual Nanoparticles in Cylindrical Nanopores. Journal of Physical Chemistry C. 116:18460-18468. abstract
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Lupoi J S; Smith E A . 2012. Characterization of Woody and Herbaceous Biomasses Lignin Composition with 1064 nm Dispersive Multichannel Raman Spectroscopy. Applied Spectroscopy. 66:903-910. abstract
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