Chemical Analysis of Nanodomains


Project Leader(s):
Emily Smith

Principal Investigators:
Ning Fang, Jacob Petrich, Emily Smith


We seek to understand the basic principles that underlie energy-relevant chemical separations; develop analytical methods to improve the sensitivity, reliability, and productivity of analytical determinations; and to develop new approaches to analysis. Our research emphasizes instrumentation and technique development highly relevant to the main focus areas of the Separation and Analysis activities of the Division of Chemical Science, Geoscience and Biosciences within the DOE Office of Basic Energy Sciences.  

The goal of this research is to develop the next generation of imaging tools and methodologies for the analysis of phenomena that occur at nanometer length scales and picosecond time scales. The developed instrumentation and methodology will be applied to model systems of interest to the DOE mission, where fundamental insight can be gained with the high spatial and temporal resolution afforded by our developed methods: chemical reac tions in heterogeneous silica supported catalysts; the organization and dynamics of mixed model lipid bilayers and cell membranes; chromatographic interactions; and heterogeneous enzyme reactions. The methods we propose to develop are:

1. High resolution total internal reflection (TIR) Raman microspectroscopy and imaging
2. Sub-diffraction limited imaging, including differential interference contrast (DIC) microscopy, variable-angle evanescent-field (EFM) microscopy, and time-resolved stimulated emission depletion (STED) microscopy
3. Novel single molecule spectroscopies


This research is supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences, and Biosciences through the Ames Laboratory.  The Ames Laboratory is operated for the U.S. Department of Energy by Iowa State University under Contract No. DE-AC02-07CH11358.


Ha J W; Chen K C; Fang N . 2013. Differential interference contrast microscopy imaging of micrometer-long plasmonic nanowires. Chemical Communications. 49:11038-11040. abstract
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Mahadevapuram R C; Carr J A; Chen Y Q; Bose S; Nalwa K S; Petrich J W; Chaudharya S . 2013. Low-boiling-point solvent additives can also enable morphological control in polymer solar cells. Synthetic Metals. 185:115-119. abstract
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Gu Y; Ha J W; Augspurger A E; Chen K C; Zhu S B; Fang N . 2013. Single Particle Orientation and Rotational Tracking (SPORT) in biophysical studies. Nanoscale. 5:10753-10764. abstract
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Marchuk K; Fang N . 2013. Three-Dimensional Orientation Determination of Stationary Anisotropic Nanoparticles with Sub-Degree Precision under Total Internal Reflection Scattering Microscopy. Nano Letters. 13:5414-5419. abstract
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Stender A S; Wei X Z; Augspurger A E; Fang N . 2013. Plasmonic Behavior of Single Gold Dumbbells and Simple Dumbbell Geometries. Journal of Physical Chemistry C. 117:16195-16202. abstract
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Xu A S; Li F L; Robinson H; Yeung E S . 2013. Can Protein Conformers Be Fractionated by Crystallization?. Analytical Chemistry. 85:6372-6377. abstract
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Wei L; Liu C; Chen B; Zhou P; Li H C; Xiao L H; Yeung E S . 2013. Probing Single-Molecule Fluorescence Spectral Modulation within Individual Hotspots with Subdiffraction-Limit Image Resolution. Analytical Chemistry. 85:3789-3793. abstract
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Stender A S; Marchuk K; Liu C; Sander S; Meyer M W; Smith E A; Neupane B; Wang G F; Li J J; Cheng J X; Huang B; Fang N . 2013. Single Cell Optical Imaging and Spectroscopy. Chemical Reviews. 113:2469-2527. abstract
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Gu Y; Sun W; Wang G F; Zimmermann M T; Jernigan R L; Fang N . 2013. Revealing Rotational Modes of Functionalized Gold Nanorods on Live Cell Membranes. Small. 9:785-792. abstract
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Meyer M W; Nguyen V H T; Smith E A . 2013. Scanning angle Raman spectroscopy measurements of thin polymer films for thickness and composition analyses. Vibrational Spectroscopy. 65:94-100. abstract
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